HRT could prevent Alzheimer's disease in at-risk women, study suggests

Hormone replacement therapy could help prevent Alzheimer's disease in women at risk of developing the condition, a study suggests.

Researchers from East Anglia and Edinburgh universities said HRT, which helps control symptoms of the menopause, is associated with better memory, cognitive function and larger brain volume in later life in women carrying a gene called APOE4.'s is more common in women than men. APOE4 is the strongest risk factor gene for the disease, though inheriting it does not mean someone will definitely develop the condition.

In the study, researchers found HRT was most effective when given during perimenopause, where symptoms build up months or years before periods stop. Professor Anne-Marie Minihane, from the University of East Anglia's Norwich Medical School, who led the study with Professor Craig Ritchie at the University of Edinburgh, said:"We know that 25% of women in the UK are carriers of the APOE4 gene and that almost two-thirds of Alzheimer's patients are women.

"In addition to living longer, the reason behind the higher female prevalence is thought to be related to the effects of menopause and the impact of the APOE4 genetic risk factor being greater in women.More on Dementia

Source: Healthcare Press (healthcarepress.net)

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