By Neha MathurAug 8 2022Reviewed by Aimee Molineux In a recent study published in Nature, researchers formed the coronavirus disease 2019 host genetics initiative to compile a genome-wide association meta-analysis of 60 studies from 25 countries. The study encompassed ~125,584 COVID-19 cases and data from over 2.5 million control populations.
The first study cohort comprised 9376 total cases, of which new cases and controls were 3197 and 1,776,645, respectively. The second and third cohorts had 25,027 and 125,584 total and 11,386 and 76,022 new cases, respectively. The control groups had 2,836,272 and 2,575,347 individuals in the second and third cohorts.
Study findings Related StoriesThe study pointed to 23 significant genome-wide loci, of which 20 loci remained substantial even after correction for multiple testing in accounting for the number of phenotypes tested. While all these gene loci showed the expected upsurge in statistical significance, only one locus did not replicate the effects between the previous and current analysis.
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