Health impact of a combination of intermittent fasting and ketogenic diet

By Dr. Sanchari Sinha Dutta, Ph.D.Jan 31 2023Reviewed by Benedette Cuffari, M.Sc. A recent opinion published in Clinical Nutrition ESPEN provides a highly detailed review of intermittent fasting and the ketogenic diet, as well as strategies to apply a combination of these approaches to manage chronic health conditions.

Time-restricted fasting is used to gradually reduce calorie intake over time. This approach considers small eating windows in the morning and early afternoon to be better than late afternoon or evening eating windows in terms of reducing fat accumulation, insulin resistance, and inflammation. Both time- and diet-restricted fasting are equally effective in managing body weight. A combination of both approaches is also effective in managing chronic diseases.

In the fasting stage, glucose still acts as the main energy fuel; however, a shift of fuel source from glucose to fatty acid is initiated. This sometimes causes flu-like symptoms, commonly known as ‘ketoflu’. Modified ketogenic diets, such as the modified Atkins diet and low glycemic index diet, were developed in the 2000s to reduce fat consumption and increase carbohydrate consumption.

This type of combination therapy could be beneficial in managing various diseases through metabolic remodeling, including diabetes, cardiovascular diseases, and autoimmune diseases. A successful application of this combination approach depends on various factors, including patient-related and diet factors.

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