Study: SARS-CoV-2 takes the bait: Exosomes as endogenous decoys. Image Credit: Meletios Verras / Shutterstock
In a study, researchers at the University of Zurich, Switzerland, identified a subset of exosomes, termed defensosomes, secreted specifically during bacterial infection. These defensosomes incorporated surface receptors to the levels typically expressed on cells and were decoys for bacterial toxins, which otherwise would have mediated toxicity through interactions with receptors on living cells.
SARS-CoV-2 infection triggers the secretion of ACE2-coated defensosomes Next, they showed that SARS-CoV-2 could trigger the secretion of ACE2-coated exosomes in cell-based assays in vitro. This induction was comparable to bacterial induction in that both required autophagy components of the host and was recapitulated by some immune stimuli.
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