By Neha MathurSep 19 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* server, a team of researchers investigated how antigen concentration and viral load in different specimen types affected the performance of severe acute respiratory syndrome coronavirus 2 rapid diagnostic tests .
About the study In the present study, researchers presented the results of reference antigen concentration measurements on specimens collected for a study conducted in Porto Velho, Brazil, in 2021 to determine the correlations between antigen concentration and viral load on RDT performance. The study population covered symptomatic, asymptomatic, and oligosymptomatic cases. Likewise, the study samples had low viral load and low antigen concentrations. Larger data sets of paired viral load and antigen concentration measurements across different sample types, variants, and different study populations may improve the ability to predict the performance of antigen detection tests in different scenarios and use cases.
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