Dysbiosis in male mice affects offspring health and placental development

May 2 2024European Molecular Biology Laboratory The gut microbiota is the microbial community that occupies the gastrointestinal tract . It is responsible for producing enzymes, metabolites, and other molecules crucial for host metabolism and in response to the environment.

The Hackett group at EMBL Rome, in collaboration with the Bork and the Zimmermann groups at EMBL Heidelberg, set out to answer this question, with their results now published in the journal Nature. The scientists showed that disrupting the gut microbiota in male mice increases the probability that their offspring are born with low weight, and are more likely to die prematurely. These findings are illustrated in this animation.

The scientists then analysed changes in the composition of important testicular metabolites. They found that in male mice dysbiosis affects the physiology of the testes, as well as metabolite composition and hormonal signalling. At least part of this effect was mediated by changes in the levels of the key hormone leptin in blood and testes of males with induced dysbiosis.

Importantly, this effect is reversible. Once antibiotics are withdrawn, paternal microbiota recover. When mice with recovered microbiota were mated with untreated females, their offspring were born with normal birthweight and developed normally as well.

Source: Healthcare Press (healthcarepress.net)

Dysbiosis Endocrine Gastrointestinal Tract Germline Metabolism Metabolites Physiology Pregnancy Reproduction Research

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