, created using mutated disease-causing parasites, prompt molecular-level changes in host cells that have specific roles in helping generate the immune response.
In developing these live attenuated vaccines, Satoskar and colleagues applied new technology to the century-old Middle Eastern practice of leishmanization—introducing the live parasite to the skin to create a small infection that once healed, leads to life-long immunity against further disease. The team used mass spectrometry at the inoculation site to identify the most prominent metabolites—the, vitamins and other small molecules produced as a result of metabolism, the many chemical reactions that keep the body functioning.
Source: Healthcare Press (healthcarepress.net)
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