TLTs are suggested to directly injure the proximal tubules and promote their proinflammatory property via producing cytokines such as interferon gamma and tumor necrosis factor alpha. Credit: Hiroko Uchida/Kyoto university
To elucidate these issues, the Kyoto-based research team used single-nucleus RNA-sequencing to investigate the interaction between renal parenchymal cells and immune cells in the kidneys of older mice.was induced in the kidney on one side in experimental mice, the kidney was harvested from both the experimental mice and control mice with no injury.
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