Can breath analysis help with early detection of aspergillosis?

Sponsored Content by Owlstone Medical LtdApr 15 2024Reviewed by Louis Castel Aspergillosis is a fungal infection caused by different species of the fungus Aspergillus, commonly found in decaying organic material.

The chance of a positive prognosis can be improved by ensuring timely access to reatment, but the symptoms of aspergillosis can be non-specific. Radiologic findings are often associated with other diseases, cell cultures lack sensitivity and need time for incubation, and definitive diagnosis is contingent on a tissue biopsy of the lung.2

Aspergillus fumigatus is considered to be the species most commonly associated with invasive aspergillosis. The pathology will vary if the host’s immune system is compromised, depending on whether the patient has neutropenia or corticosteroid-induced immunosuppression. The unique metabolic processes of fungi mean that most of these products will not occur via endogenous processes in human metabolism. Therefore, they could potentially serve as practical exogenous biomarkers of invasive aspergillosis.

Figure 2. Secondary metabolites found on breath in patients with invasive aspergillosis and not in healthy controls. Image Credit: Owlstone Medical Ltd

Aspergillosis

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