Can studying the microbiome help with cancer research?

Sponsored Content by Owlstone Medical LtdApr 15 2024Reviewed by Louis Castel Cancer is a major concern when it comes to global health issues. The World Health Organization claims that all cancers were responsible for an estimated 10 million deaths in 2020, making it a leading cause of death worldwide.1

This underscores one key mechanism through which the microbiome can interact with the body and affect cancer development and treatment. Several microbial compounds that can be leveraged as biomarkers are also volatile and, therefore, could be measured in exhaled breath. Therefore, breath analysis could offer a sturdy platform for investigating the clinically relevant links between the microbiome and cancer.

This mucus barrier is crucial; it maintains the flow and balance of nutrients in the enterocytes and toward the symbiotic microbiota. This protects the intestine against mechanical stress, keeping the epithelial cells attached to the gut microbiota to shield it from potentially harmful secreted compounds.

One of the most abundant symbiotic bacterial phyla inhabiting the intestinal tract is Firmicutes, and alongside Bacteroides, comprises 95% of the microbial colonizers of the gut.9,10 All in all, this indicates a fundamental mechanism through which SCFA levels produced by the gut are associated with CRC risk and development. Therefore, SCFAs and other microbially produced compounds could be key biomarkers for evaluating the predisposing factors an individual may be exposed to evaluate a risk of cancer development and monitoring cancer progression.

As breath is virtually inexhaustible, collecting significant volumes at frequent intervals is possible, and any compounds acquired can be pre-concentrated prior to analysis.

Source: Healthcare Press (healthcarepress.net)

Microbiome

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