British patients test world’s first personalised mRNA jab for melanoma

Consultant Dr Heather Shaw speaking to patient Steve Young, with an MRI of his brain on the screen, during a consultation at University College Hospital Macmillan Cancer Centre in London

A stage 2 trial of the jab, involving pharma firms Moderna and MSD, found it dramatically reduced the risk of the cancer returning in melanoma patients. “This is a really finely honed tool. To be able to sit there and say to your patients that you’re offering them something that’s effectively like the Fat Duck at Bray versus McDonald’s – it’s that level of cordon bleu that’s coming to them.

In order to create the jab, a sample of tumour is removed during the patient’s surgery, followed by DNA sequencing and the use of artificial intelligence.Dr Shaw said: “This is very much an individualised therapy and it’s far cleverer in some senses than a vaccine. “So there’s nothing to see on scans, but if there are some cells that have escaped that are below the detection of imaging… what we’re trying to do is, on a patient-by-patient basis, give treatment to eradicate any of those rogue cells that might be sitting about.

The phase 3 global trial will now include a wider range of patients, and hopes to recruit around 1,100 people. “So it appears to be relatively tolerable and actually no worse than having a flu vaccine or a Covid jab for the majority of patients,” she said.

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