Hayashi and his team previously found a way to take skin cells from a female mouse and transform them into an egg that could be used to give birth to healthy pups.Just like humans, male mice have both an X and Y chromosome, while females have two X chromosomes.
Using a fluorescent protein and a drug called reversine, the researchers managed to duplicate the existing X chromosome in these cells, creating an XX set.The cells were then used to create eggs, which were fertilized with the sperm of a different male mouse and implanted into the uteruses of surrogate female mice.Out of 630 attempts, seven pups were born, representing a success rate of just over one percent.
But Gonen warned that the process was currently “extremely inefficient”, with 99 percent of the embryos not surviving.
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