Researchers say they have removed HIV from the DNA of mice, an achievement the scientists say could be an early step toward an elusive cure for humans.
"We knew what we needed to do, but the technology was unavailable," Khalili told The Washington Post, saying he and his team had been awaiting a tool like CRISPR to combat a virus that "becomes part of the fabric of our chromosomes." With gene editing finally a reality, he said, "the outcome was amazing."
Previously, Khalili's team at Temple had found a way to remove significant amounts of HIV DNA from rats and mice. But the technique could not completely remove the infection. So Khalili's lab joined forces with a University of Nebraska Medical Center lab attacking the problem in a different way. Together, the scientists combined the gene-editing strategy with a drug designed to beat back HIV.
But if Khalili's team is able to move forward with trials with humans, it will use standard drugs rather than the one developed by UNMC's lab, since it probably would not be approved yet for use, Khalili said. "For this approach to work, they have to really knock out 100 percent of the genomes - you can't leave anything behind," Deeks said. "One of them can reignite the whole process."
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