Patrick Soon-Shiong. Picture: Getty Images/Kevork Djansezian
Most vaccines work to elicit immune proteins called antibodies blocking the spike protein that the coronavirus uses to enter cells. San Diego-based ImmunityBio is trying to raise T-cells against both the spike and another viral protein, called the nucleocapsid, Soon-Shiong said. This could make it ideal for use as a booster for different types of vaccines, he said in an interview.
The goal of the shot is to produce “potent T-cells so you can kill the factory that is making the virus,” Soon-Shiong said, and “help overcome this challenge of mutations that happens continuously”. Results from the company’s one US study show that ImmunityBio’s candidate generates T-cell responses equal to those in people that have previously had a Covid-19 infection. While it’s been effective against some other variants, it’s still being tested against Delta.
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