TOKYO - Scientists have generated early-stage human embryo models that could help shed light on the"black box" of initial human development stages and improve research on pregnancy loss and birth defects.
The teams, whose research was published in the journal Nature, believe the models dubbed"blastoids" will aid research on everything from miscarriages to the effects of toxins and drugs on early-stage embryos. At the moment, research on the earliest days of embryonic development relies on donated blastocysts from IVF treatment.So being able to generate unlimited models could be a game-changer, said Jose Polo, a professor at Australia's Monash University, who led the second research team.
Polo's team instead started with adult skin cells, but both teams ended up with effectively the same result: the cells began to organise themselves into blastoids, featuring the three key components seen in a human blastocyst. Both teams' blastoids ended up containing cells of unknown types, and they lack some elements that come specifically from the interaction between a sperm and an egg.
"To capitalise on the discovery, the process will need to be more controlled and less variable," he said.
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