Mixed results for arthritis drug repurposed as COVID-19 treatment

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Unlike steroids, which suppress the immune system more broadly, tocilizumab blocks a particular signaling protein from triggering inflammation.

WASHINGTON - A trio of new studies published in JAMA Internal Medicine on Tuesday examining the efficacy of an arthritis drug against COVID-19 showed inconsistent results.

The risk of death at 30 days was 28 and 38%among tocilizumab-treated and non-tocilizumab-treated patients, respectively. The two other studies, carried out in France and Italy, were randomized controlled trials, considered the gold standard for clinical research, in which patients are allocated a treatment by chance.

Writing in a related editorial, Doctor Jonathan Parr, an infectious disease specialist at University of North Carolina at Chapel Hill said: "Newly released randomized trials suggest a potential role for tocilizumab in COVID-19 but do not show clear evidence of efficacy. Tocilizumab belongs to a class of drug called "monoclonal antibodies" which have received significant attention after US President Donald Trump received a dose of the lab-made molecules for his COVID-19.

 

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