How does resistance to disinfectants happen? We’re on the road to answering the question

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Covid-19 has had a significant impact on our lives. One effect that could yet be seen might be the development of bacterial resistance to disinfectants, as a result of the overuse of substandard disinfectants.

We set out to identify which microorganisms were resistant to which disinfectants. We took environmental samples and tested the levels of disinfectant resistance.

We did full genome sequencing of this isolate and compared the genes to closely related isolates. We found a large number of unique genes in this highly resistant strain. We also found that the highly resistant strain of bacterium can grow on the disinfectants that contain sub-minimum inhibitory concentration levels. This means that the concentration of the disinfectant used is below the lowest concentration needed to kill the pathogen. In other words, the pathogen is exposed to the chemical but at such low levels that the chemical cannot kill the pathogen. This allows the pathogen to develop resistance.

 

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