The South African study enrolled 100 men and women, aged between 18 and 40 years from Cape Town, Klerksdorp and Soweto. They were followed for a little longer than a year. The participants were given the initial vaccine and then booster shots. The aim was not to directly test the efficacy of the vaccine ; it was only to see whether people’s immune systems responded to it.
To the surprise of the researchers, the South African population had an even stronger immune response than the Thai population. This was surprising, given that the clades are different in the two populations. The study team acknowledges that factors such as the types of HIV circulating locally, and genetic factors, may have influenced immune responses in the study. Some scientists also think that each region of the world may need a separate type of HIV vaccine based upon their circulating strains.
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