New York - US-based pharmaceutical major Moderna's experimental vaccine, mRNA-1273, designed to protect against Covid-19 virus, was generally well tolerated and prompted neutralising antibody activity in healthy adults, say researchers.
In the Phase 1 trial, led by Lisa A Jackson of Kaiser Permanente Washington Health Research Institute in Seattle, the 45 participants ages 18 to 55 years received the candidate vaccine. The results from the first stage of Moderna's vaccine trial showed the first 45 participants developed antibodies to the virus.The interim analysis included results of tests measuring levels of vaccine-induced neutralising activity through day 43 after the second injection.
However, more than half of the participants reported fatigue, headache, chills, myalgia or pain at the injection site. Systemic adverse events were more common following the second vaccination and in those who received the highest vaccine dose.
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