These precautions are crucial, since you can spread the virus to others during a Paxlovid rebound, the advisory said. Right now, experts don’t know whether the likelihood of transmission during this rebound period is any different than the likelihood of transmission during the initial onset of symptoms–only that it’s possible to spread the virus during a recurrence of symptoms. They also don’t know whether rebound symptoms are particular to Paxlovid, Dr.
Given reports of Paxlovid rebound, though, people who finish the treatment should stay alert for COVID-19 symptoms. They should test immediately upon detection of those symptoms, even if they’ve previously tested negative following Paxlovid treatment, per the CDC. If you’re experiencing symptoms but your at-home test is negative, consider taking a PCR test just to be sure, since they’re more sensitive than at-home tests, Dr. Russo says.
All that said, the possibility of rebound symptoms should not discourage anyone from taking Paxlovid if their doctor recommends it, Dr. Russo says. “Paxlovid is a very important tool to minimize progression of disease in people at risk of developing severe disease,” he says, adding that unvaccinated individuals fall in this group.
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