Withdrawal of Aspirin Post-PCI Reduces Major Bleeding by Over 50%

Withdrawing aspirin post- PCI reduces major bleeding by more than half, maintaining safety and efficacy in high-risk heart patients on ticagrelor.

These are the results from the ULTIMATE-DAPT study announced during a late-breaking trial presentation at the American College of Cardiology Scientific Sessions on April 7, and published inThis is the first and only trial to test high-risk patients with recent or threatened heart attack taking ticagrelor with a placebo starting one month after PCI, and compare them with ACS patients taking ticagrelor with aspirin over the same period.

The primary efficacy endpoint of clinically-relevant bleeding, defined as BARC types 2, 3 or 5 bleeding, was assessed in the intention-to-treat population between one-month and twelve-months post-PCI in patients who were event-free after one month of ticagrelor and aspirin. Switching to ticagrelor monotherapy at one month resulted in a 55-percent reduction in the hazard of clinically relevant bleeding compared with continuing ticagrelor plus aspirin over the ensuing 11 months.

Aspirin PCI High-Risk Heart Patients Ticagrelor Bleeding Outcomes Study

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