When Audra was a teen, she began to buckle under uncontrollable feelings of doubt, self-consciousness, and panic that made going to school or even hanging out with friends torturous. “I could barely make it through the day without feeling like I was dying,” she remembers now. She learned she had anxiety and ADHD at 15, but the diagnosis just gave a name to her issues—it didn’t solve anything.
: One-tenth of the amount needed to trip on psilocybin-containing mushrooms , one day on, then two days off for about a month. Most people take between 0.1 and 0.4 grams of psilocybin-containing mushrooms while microdosing, which doesn’t produce the technicolor trips of Grateful Dead concerts and hippie communes. Of course, with no one prescribing this self-treatment, individuals tweak the regimen based on their own experience.
Mercedes has struggled with mental health issues all her life, with her first major depressive episode coming in her late teens. Later, she was diagnosed with posttraumatic stress disorder. For years, Mercedes tried antidepressants and “substances, alcohol, drugs—anything to distract myself from feeling how I was feeling,” she remembers. Then two years ago, her therapist mentioned microdosing, and it spurred her to seek out more information at a spirit medicine conference.
This effect is more widely witnessed—and accepted by the scientific community—in large doses of psychedelics such as psilocybin. Doctors and therapists have begun to embrace therapy-assisted trips to help people with treatment-resistant depression as well as cancer patients and those staring down death.
When Jean, who works in university administration in the Washington, D.C. area, tried microdosing two years ago, she was hoping to take advantage of the reported creativity boost for her work and personal art, as well as benefit from the mood boost, since she was going to therapy already. After lurking on microdosing forums and talking to people who had tried it themselves, she started eating a mushroom cap about the size of her fingernail every morning before work.
Many people are trying “heroic doses,” too, either independently or while supervised by therapists or other “guides.” Sue, a mom in Portland, Oregon, had tried dozens of antidepressants and mood stabilizers over nearly three decades without much relief and sometimes with side effects like fevers and rashes.
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