Why Does the Coronavirus Hit Men Harder? A New Clue

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The coronavirus may infect anyone, young or old, but older men are up to twice as likely to become severely sick and to die as women of the same age.Why? The first study to look at immune response by sex has turned up a clue: Men produce a weaker immune response to the virus than do women, the researchers concluded.The findings, published Wednesday in Nature, suggest that men, particularly those older than age 60, may need to depend more on vaccines to protect against the infection.'Natural infection is clearly failing' to spark adequate immune responses in men, said Akiko Iwasaki, an immunologist at Yale University who led the work.The results are consistent with what's known about sex differences following various challenges to the immune system.Women mount faster and stronger immune responses, perhaps because their bodies are rigged to fight pathogens that threaten unborn or newborn children.But over time, an immune system in a constant state of high alert can be harmful. Most autoimmune diseases -- characterized by an overly strong immune response -- are much more prevalent in women than in men, for example.'We are looking at two sides of the same coin,' said Dr. Marcus Altfeld, an immunologist at the Heinrich Pette Institute and at the University Medical Center Hamburg-Eppendorf in Germany.The findings underscore the need for companies pursing coronavirus vaccines to parse their data by sex and may influence decisions about dosing, Altfeld and other experts said.'You could imagine scenarios where a single shot of a vaccine might be sufficient in young individuals or maybe young women, while older men might need to have three shots of vaccine,' Altfeld said.Companies pursuing coronavirus vaccines have not yet released clinical data analyzed by the participants' sex, but the Food and Drug Administration has asked them to do so, as well as by racial and ethnic background, said Dr. William Gruber, a vice president at Pfizer.Iwasaki's team analyzed immune responses

August 27, 2020, 10:00 PMThe coronavirus may infect anyone, young or old, but older men are up to twice as likely to become severely sick and to die as women of the same age.

The results are consistent with what’s known about sex differences following various challenges to the immune system. The findings underscore the need for companies pursing coronavirus vaccines to parse their data by sex and may influence decisions about dosing, Altfeld and other experts said. The researchers also analyzed data from an additional 59 men and women who did not meet those criteria.

But “women who are older — even very old, like 90 years old — these women are still making pretty good, decent immune response,” she added.

Source: News Formal (newsformal.com)

 

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Why does the coronavirus hit men harder? It's sexism.

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