In patients with localized pancreatic ductal adenocarcinoma , failure to undergo resection following neoadjuvant chemotherapy is common and associated with worse survival. Researchers identified few risk factors associated with failing to undergo surgical resection but did highlight weight loss during neoadjuvant therapy as one significant factor.
Overall, 73 patients had a successful pancreatectomy, while 29 patients did not undergo surgical resection. The reasons varied, with distant progression during neoadjuvant therapy and therapy-related toxicity being the most common factors, but occult metastatic disease , patient preference , complications during surgery also playing a role.Patients who underwent surgical resection had a longer median overall survival and 2-year survival rate .
Source: Healthcare Press (healthcarepress.net)
Pancreatic Cancer Cancer Of The Pancreas Resection Neoadjuvant Chemotherapy Toxicology Toxicity Poisoning Toxins Biologic Therapy Biologics Weight Management Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Surgery Weight Loss Practice Management Revenue Preoperative
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