When good bacteria go bad: New links between bacteremia and probiotic use

Researchers discovered a concerning association between bacteremia and probiotic use, particularly with Clostridium butyricum MIYAIRI 588. Whole-genome sequencing revealed that all C. butyricum bacteremia strains were probiotic derivatives. Out of 6,576 cases of positive blood cultures, C. butyricum was detected in only five cases, all derived from probiotics.

Probiotics offer a range of health benefits, but their adverse effects can occasionally lead to bacteremia, wherein bacteria circulate in the bloodstream throughout the body. In Japan, MIYAIRI 588 is commonly used, yet the prevalence and characteristics of bacteremia caused by this strain, as well as its bacteriological and genetic profile, remain unknown.

"Probiotics can provide a variety of health benefits, but this study shows that even such agents can present with rare but serious adverse events," says study lead author Ryuichi Minoda Sada."Our findings underscore the risk for bacteremia resulting from probiotic use, especially in hospitalized patients, necessitating judicious prescription practices."

Ryuichi Minoda Sada, Hiroo Matsuo, Daisuke Motooka, Satoshi Kutsuna, Shigeto Hamaguchi, Go Yamamoto, Akiko Ueda.Researchers have been working on a novel solution to prevent NEC. They have developed a novel probiotic system that harnesses the durability of biofilms to improve the administration of probiotics to ...

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