raphs and charts don’t always tell the whole story. Numbers can be deceiving. But anyone who looks at U.S. trends in asthma mortality can see, without squinting, that things are moving in the right direction.found that from 1999 to 2015, asthma mortality fell by 43%. “The decrease in asthma-related mortality was consistent in both sexes and in all race groups, with the largest decrease in patients older than 65 years,” the authors concluded. Figures from the U.S.
Together, these and other new advancements are producing real and measurable improvements in patient access and outcomes. “It is really a very exciting time in asthma research right now,” says Dr. Derek Chu, an assistant professor of medicine and a researcher in allergy and clinical immunology at McMaster University in Canada. “There’s a lot in development for both mild and moderate-severe asthma.”Read More:In 2003, the U.S.
Some of the newest biologics take aim at two specific immune system proteins: thymic stromal lymphopoietin and interleukin 33. “These two activate cells in the airways, which leads to a release of all these [inflammation] players,” Brightling explains. Because these two are farther “upstream” than some of the pathways targeted by older biologics, mellowing their activity may produce broader benefits, he says.
Unfortunately, not everyone who would benefit from these drugs is getting them. “Awareness of this medicine is not what it should be,” Jackson says. “A lot of patients continue to have asthma attacks and their doctor hasn’t picked up on the fact that there are newer therapies.
To be effective, the newest treatments have to find their way to the patients who will benefit from them most. Phenotyping plays a crucial matchmaking role.Every asthma specialist knows that getting patients to reliably take their medicine can be a struggle. Particularly among young people with severe asthma, adherence is often poor.
Some of these smart-inhaler technologies are already available . For example, patients can buy inhaler sensors that will remind them when to take their meds. Some health care systems have also set up office notifications similar to the type Gupta and her team studied. But for the most part, these new technologies are not widely deployed. “My dream is that every time a patient uses their inhaler, this information would go straight into their electronic medical chart,” she says.
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