“The fact you have it in over 70% of cases does suggest that it must have a role,” says Deirdre Kelly, a pediatric hepatologist at Birmingham Children’s Hospital, one of a group of technical experts advising UKHSA.
The skeptics note that liver biopsies from the affected children have failed to find cells stuffed with adenovirus, a classic sign of adenoviral hepatitis. They say, sometimes heatedly, that the agencies are overlooking a more likely culprit, SARS-COV-2. Only some of the children with hepatitis are currently infected with SARS-CoV-2;in the United Kingdom, the figure was 18%. But a recent CDC study estimated that younger than 12 have been infected, 31% of them between December 2021 and February. A publication by the European Centre for Disease Prevention and Control last week reported evidence of prior SARS-CoV-2 infection in 14 of 19 children with hepatitis. It also showed that most of the cases in Europe, during a large Omicron wave.
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