Weight loss drugs can lead to muscle loss, too. Is that a bad thing?

“If you can maintain your muscle mass, you could have more sustained weight loss because your metabolic rate would not be reduced,” said Dr. Louis Aronne, director of the Comprehensive Weight Control Center at Weill Cornell Medicine in New York.

When the body isn’t getting as much energy from food, it pulls from reserves of energy stored as fat and muscle, starting primarily with fat. While it’s normal for some of this extra energy to be pulled from muscle, the body may need to pull more energy from muscle if a person is, such as 5 to 10 pounds a week instead of around 2 pounds.

“While lean mass loss is concerning, at the end, you may actually end up with a little more lean mass compared to other components such as body fat,” said Almandoz, who has worked as a consultant for Novo Nordisk and Eli Lilly.doesn’t come from increased muscle, it comes from increased fat mass, particularly in the abdomen,” according to Aronne, who is a consultant for Eli Lilly. Figuring out how to lose fat but not muscle would be the “holy grail” of weight loss, he said.

A new analysis of data from the same trial found that after 72 weeks of taking the drug, about 25% of the weight participants lost was lean mass. However, the participants had an overall healthier body composition. Aronne, who worked on the trial, presented the findings this week at the European Congress on Obesity in Dublin. The analysis has not yet been published in a peer-reviewed journal.

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