Save Your Skin Foundation“A number of studies have challenged this model in recent years,” Judson-Torres said. “These studies have provided excellent data… but what they have all lacked is an alternative explanation, which has remained elusive.”
The research team looked at moles and melanomas using transcriptomic profiling, which helps them see molecular differences between moles and melanomas, and digital holographic cytometry, which tracks changes in human cells. They discovered that additional gene mutations aren’t the only way these skin cells turn into melanoma. The melanocytes are also impacted by environmental signals, which indicate to them whether they should divide uncontrollably or simply stop dividing .
“Origins of melanoma being dependent on environmental signals gives a new outlook in prevention and treatment,” he said. “It also plays a role in trying to combat melanoma by preventing and targeting genetic mutations. We might also be able to combat melanoma by changing the environment.” The researchers hope to use the information to continue research on what kinds of environmental signals are significant in impacting these cells. And the study can help doctors with early detection of cancerous changes in the blood, Judson-Torres said.Melanoma is distressingly common, and is on the rise — especially in women under 40. In the 1930s, it affected about one in 1500 people, according to the— less than 100 years later, that number has ballooned to one in 63 people.
As with any form of cancer, early detection can make an enormous difference. Seek medical help if you develop a new mole, or if an existing appears to change in size, shape or colour. But remember that melanoma doesn’t always show up in the form of a mole, and they can sometimes be hidden in areas that don’t get a lot of sun exposure, like the bottom of the feet.
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