Watching the Brain Get “High” on Cannabis in “Real Time”

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Here's what we know happens in people's brains when they experience marijuana-induced euphoria

, most of the endorphins, and probably all of the seven known endogenous cannabinoids that are produced in the brain. Similarly, many different brain regions are involved in the production of the subjective feelings of euphoria, including the medial prefrontal cortex, anterior cingulate gyrus, nucleus accumbens and insular cortex.circuitry that is shared by quite diverse types of pleasures.

The subjects who received THC demonstrated greater resting-state functional connectivity between the right NAcc and the medial prefrontal cortex. The “higher” the subjects rated themselves, the greater was the connectivity between the NAcc and medial prefrontal cortex.

 

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