1 December is World AIDS Day, and the focus this year is “End inequalities. End AIDS. End pandemics.” The theme could equally be invoked for COVID-19, which shares commonalities with human immunodeficiency virus and AIDS in terms of disproportionately affecting the most socioeconomically disadvantaged global populations, and the staggering human toll.
In August 2021, results from the Imbokodo trial of a vaccine developed by Janssen and comprising an Ad26 vector and protein boost showed evidence of only 25%against HIV acquisition in young women in sub-Saharan Africa, relative to placebo. The Mosaico trial of the same vaccine platform in a different study population — cis-gender men and transgender people in the Americas and in Europe — remains ongoing, but is the only large HIV vaccine trial currently underway.
But whereas HIV trials typically take years from concept to clinic, the accelerated pace of COVID-19 vaccine development — in which trials were initiated within months of their conceptualization — indicates that these delays can and should be curtailed.
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