, found vaccination reduced the likelihood of long COVID after infection by only about 15%. There was no difference in type or severity of long COVID symptoms between vaccinated and unvaccinated patients.
The researchers also compared hospitalized patients with breakthrough COVID to hospitalized patients with seasonal influenza. "Breakthrough SARS-CoV-2 was associated with higher risk of death... than flu," study leader Dr. Ziyad Al-Aly of the VA St. Louis Health Care System said in a tweet. "The findings indicate that reliance on vaccines as our sole line of defense is not an optimal strategy," he told Reuters.
"Mutations alone cannot answer the question" of whether a variant will take hold, said Venky Soundararajan of Massachusetts-based data analysis company nference. To estimate a variant's potential impact, the "distinctiveness" of its mutated gene sequences relative to previously circulating variants must be considered in the context of each geographical area, Soundararajan said.
The researchers are working with the U.S. National Institutes of Health on a system that will alert public health officials when new variants arise to which communities are likely to be vulnerable. Those are variants that have the most differences both from the original version of the virus on which current COVID-19 vaccines are based and from variants to which local residents have acquired some immunity via herd exposure.
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