, demonstrates how the protein known as ‘numb’ regulates intracellular tau levels, making numb a potential therapeutic agent for tauopathies.Tauopathies are a broad group of neurodegenerative diseases that include, but are not limited to,disease. These diseases have increased intracellular tau levels, which ultimately becomes toxic to neurons and cause their degeneration.
These findings led the IRCM team to wonder if, conversely, overexpression of numb could decrease tau levels and act beneficially to slow neuron loss.In line with this hypothesis, the scientists observed that overexpression of a specific form of the numb protein called Numb-72 decreased tau levels and slowed down the death of retinal neurons in animal models of tauopathy.
Source: Healthcare Press (healthcarepress.net)
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