Researchers have identified how the Ebola virus reproduces by interacting with the human protein ubiquitin, revealing a new target for therapeutic intervention. This finding, part of a collaborative study involving experts in various medical fields, offers insights into viral replication processes and potential pathways for developing effective Ebola treatments.Scientists in Canada and the U.S.
“Advanced computational modeling by our team here at UdeM predicted the binding interface between a viral protein, VP35, and the ubiquitin chains in human cells, and identified potential chemical compounds that could disrupt this interaction,” he said. The new study unravels some of the molecular intricacies of Ebola virus replication, shedding light on key proteins and pathways involved in the process. Using advanced molecular and cell biology, biophysics and computational techniques, the researchers were able to clarify structural and functional aspects of viral and human proteins interacting in a manner critical for viral replication.
“This research underlines the importance of trying to understand the complex workings of viruses such as Ebola, and to develop innovative strategies to combat them,” said Najmanovich.
Source: Tech Daily Report (techdailyreport.net)
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