"The incidence of locoregional recurrence observed in this study was reassuringly low" and"disease-free survival was not associated with RNI receipt," even among women who did not get chemotherapy, the authors conclude. The results inform risk/benefit discussions about RNI, particularly that"omission of chemotherapy is not itself an independent indication for RNI.
"The work was led by Reshma Jagsi, MD, DPhil, of Emory University, Atlanta, Georgia, and published July 6 inAs an observational study, confounding by indication is likely and thus limits the ability to estimate treatment effects. Follow-up was relatively short.The work was funded by the National Cancer Institute and the Susan G. Komen Foundation. Investigators reported ties to Merck, Eisai, AstraZeneca, Pfizer, and other companies.
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