). Likewise, at least three macrophage subpopulations are found within steady-state adipose tissue and intestine, including one resembling TLF). Thus, by understanding that a common substructure exists, we may make direct comparisons between studies.
While a universal framework that is fully conserved across mammalian tissues would provide a simplified and ideal model, the reality is more complex, with nuanced similarities and some exceptions, which we bring to light here. The present study establishes a restricted number of biological commonalities in 17 murine organs. Whether this system is conserved in different organs beyond those we have investigated remains unknown.
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