The last century revealed our DNA's secrets and lingering mysteries

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Most of our textbook notions of how the information of life is encoded, the details of how it’s passed on and how it makes us who we are, were uncovered during the 20th century. SN100

. So you can identify the part of the world that people’s DNA came from. And that gets into a lot of discussion about race, and whether that has a biological basis, and what that might mean for medicine.because it’s based a lot on the DNA of people of European ancestry

Francis Collins, who led the Human Genome Project as director of the National Human Genome Research Institute, described the genetic instruction manual, or “Book of Life,” as three books – “a history book,” “a shop manual” and “a transformative textbook of medicine.”There’s no question that the successes in genomics that we’ve been discussing are worth talking about and worth showcasing. At the same time, I’m very honest in saying that, as a field, we have not been perfect.

I absolutely envision a time where people will get their complete genome sequenced end to end as part of their medical care, and maybe even at birth. I don’t think we’re there yet. But I truly believe that we will want that information as part of medical management. And I fully believe that technologies will become available and will be inexpensive enough to make it worthwhile. But those predictions are going to have to be based on evidence that indeed that’s feasible and valuable.

. Right? Can you talk a little bit about what it means to have a complete human genome sequence and what it took to get there?When the genome project ended, we attempted to be fairly transparent that we were declaring the genome project ending. We had generated the first reference sequence of the human genome to the best of our abilities that was essentially completed. By essentially, it was a great, great, great majority, well over 90 percent complete.

 

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You will probably find Scheherazade numbers

YES

That is interesting.

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For the first 1,000 years CE, it was the law of the land enforced by his holiness, 'It is entirely possible to know too much.' Could we be reaching that point. Nobody really wants to know what they truly are.

Back in '86-87 I worked on the team at Caltech that built the first automated fluorescent DNA sequenator, the machine that cracked the human genome. I was a co-author on the paper in Nature, as an undergrad, for the software that extracted the sequence.

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