The Gut Microbiome May Unlock New Treatment Paradigms For Neurological Diseases

Biden Slips On Air Force One Stairs After Staff Try To Prevent Major Falls As Gaffes Raise Concerns About His AgeAt the simplest level, we now know that microbes in the intestines can communicate directly with the CNS through the vagus nerve, which senses activity throughout the gastrointestinal tract and runs from the gut to the brain.

The most successful non-pharmacological treatment for epilepsy has long been the ketogenic diet and inhas begun to suggest that the diet’s renowned anti-seizure effects are in fact mediated by the microbiome. Bloom is also investigating whether this same oral therapeutic can offer clinical benefits for patients with ALS through addressing the underlying oxidative stress that is a critical factor in the progression of the disease. Preclinical studies using mouse models of ALS have shown that this therapeutic can attenuate motor neuron loss as well as increase lifespan and motor coordination in these mice. The company intends to conduct a Phase 2 clinical trial in ALS patients next year.

The company has developed an experimental product they describe as a tasteless and odorless powder formulation that can be mixed with soft food and taken orally. It is designed to bind to these metabolites in the gut before they can get into circulation. Right now, the product is in a Phase 2b study conducted across multiple centers in the United States, Australia and New Zealand, with data anticipated to be reported in the first quarter of 2024.Yet there are still considerable challenges.

“We don't just look at the bacteria, but also viruses and fungi in the gut, and they all interact to some extent,” says Sharma. “This is important to model because for example you could try to medicate with a bacteria, but that bacteria isn’t going to do very well if surrounding phages - viruses which attack a particular species of bacteria - act to keep it in check.”

Source: Healthcare Press (healthcarepress.net)

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