The Big Remaining Questions About the New Bivalent COVID Boosters

from Pfizer and Moderna that have been reformulated to target both the original strain of the coronavirus and the lineage of the Omicron variant, including BA.4 and BA.5, which continue to make up nearly all new cases in the U.S. The CDC has recommended that everyone 12 and over receive the updated formula whenever they are next eligible for a booster, and countless Americans have been getting the shots as the new boosters continue to become more widely available across the country.

That doesn’t mean the updated vaccines are less safe than their predecessors; these formulas are just slightly tweaked versions of the BA.1 reformulations that human trials showed were just as safe as the original COVID vaccines. That fundamental safety is extremely unlikely to have changed because of those tweaks. But what it does mean is thatfrom human trials that the BA.4/5-reformulated vaccines are actually better than their predecessors.

They point out that the data from the clinical trials of Pfizer and Moderna’s BA.1-targeting formulas indicated they only offered a slight improvement in producing more neutralizing antibody titers than the original formulas. Others,effective than the original formula. And it also remains unclear just how much of a benefit any booster shotFast-tracking the BA.

This is Russian Roulette except this time it's with a syringe

No thanks.

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