The allure and dangers of experimenting with brain-dead bodies

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For scientists who perform medical research on the recently deceased, there are few regulatory or ethical guardrails.

This article was originally featured on Undark. When the Philadelphia-based company Bioquark announced a plan in 2016 to regenerate neurons in brain-dead people, their proposal elicited skepticism and backlash. Researchers questioned the scientific merits of the planned study, which sought to inject stem cells and other materials into recently deceased subjects. Ethicists said it bordered on quackery and would exploit grieving families. Bioquark has since folded.

The family of Alva Capuano lived through such a pause in July 2022, when she was declared brain dead after being discovered unconscious in her home. Capuano had elected to be an organ donor. But after enduring Type 1 diabetes, a kidney transplant, and complex infections over the course of her life, her body was worn out, and many of her organs were unsuitable for donation. “We got to a point where it just became very trying on us,” said Tim Capuano, Alva’s son.

 

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