Technology used in J&J vaccine could explain the risk of extremely rare blood clots

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One person has died and another is in critical condition after getting the Johnson & Johnson vaccine. But is the shot to blame?

Experts believe it's possible that on rare occasions, the adenovirus itself could lead to clotting, due to a reaction involving platelets.

Platelets play a critical role in blood clotting, which is important for healing cuts and other wounds. When an injury occurs, platelets in the blood are activated, rushing to the site of the injury and forming a clot. Experts hypothesize that in very rare instances, the adenoviruses used in the Johnson & Johnson and the AstraZeneca COVID-19 vaccines might prompt the body to make antibodies similar to what's seen in heparin-induced thrombocytopenia.

For those with a cerebral venous sinus thrombosis,"heparin may be dangerous, and alternative treatments need to be given, preferably under the guidance of physicians experienced in the treatment of blood clots," Marks said Tuesday.

 

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