Structural insights into the HBV receptor and bile acid transporter NTCP - Nature

, and perhaps 15 million also carry the satellite virus HDV, which confers even greater risk of severe liver disease. Almost ten years ago the HBV receptor was identified as NTCP , which interacts directly with the first 48 amino acid residues of the N-myristoylated N-terminal preS1 domain of the viral large protein. Despite the pressing need for therapeutic agents to counter HBV, the structure of NTCP remains unsolved.

Jae-Hyun Park, Zeyu Jin, Hisashi Yoshida, Mio Ohki, Naito Ishimoto, Kenji Mizutani, Jeremy R. H. Tame & Sam-Yong Park Department of Virology II, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, JapanDepartment of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South KoreaPCG-Biotech, Ltd, Yonsei Engineering Research Park 114A, Yonsei-Ro 50, Seoul, South KoreaLaboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, JapanDepartment of Biological...

Laboratory of Biomembrane Dynamics, Graduate School of Medical Life Science, Yokohama City University, Tsurumi, Yokohama, Japan

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