Sinonasal Symptoms Help Predict Granulomatosis With Polyangiitis Relapse

Patients with granulomatosis with polyangiitis who scored high on a sinonasal symptom test are nearly three times as likely to relapse, according to a new study.

Researchers used data from a prospective, longitudinal cohort study through the University of Pennsylvania Vasculitis Center from 2016 to 2022. They included 107 patients with GPA, 40 patients with. The tool asks patients to rate a list of symptoms from 0 to 5 in five categories: Rhinologic, extra-nasal, ear and face, psychologic, and sleep. The possible total score ranges from 0 to 110.

Even in remission, patients with AAV generally had on average higher SNOT-22 scores than healthy comparators . Higher disease activity also correlated with higher SNOT-22 scores. "Interestingly, among patients with GPA, SNOT-22 scores are elevated months to years prior to onset of systemic relapse but remain low in patients in sustained remission," the authors wrote., an adjunct associate professor of medicine at the Boston University Chobanian & Avedisian School of Medicine and a rheumatologist at the VA Boston Healthcare System, Boston, Massachusetts.."There are very few clinical trials, and we need better outcome measures like this.

Source: Healthcare Press (healthcarepress.net)

Vasculitides Angiitis Granulomatosis Wegener's Granulomatosis Wegener Granulomatosis Otolaryngology ENT Specialty Head And Neck Surgery ENT Speciality Massachusetts Pennsylvania Airway Airway Management Management Of The Airway Arthritis Joint Inflammation Biomarker Biological Marker Multi-Biomarker Disease Activity MBDA Multibiomarker Disease Activity Remission

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