VENICE, Italy — Four-year data from the SELECT cardiovascular outcomes trial show that the anti-obesity drug semaglutide leads to clinically significant and durable weight loss as well as improvements in waist circumference and waist circumference-to-height ratio , in patients with preexisting cardiovascular disease , overweight or obesity, and without diabetes.
"Here we see that an obesity medication can reduce heart attack, stroke, and heart disease death in individuals with obesity who had had a prior heart attack, stroke, or peripheral artery disease but who did not have diabetes and the reduction was meaningful — by 20%," she emphasized. Markers of obesity including body composition and fat distribution : -11.1% vs -7.5% with< .0001."We think this is due to greater exposure to drug levels. There was also an effect across age, but it was not clinically significant. Everyone was getting some effect of weight loss."
Overall, adverse events were fewer in those patients treated with semaglutide compared with placebo, and this was primarily driven by reduction in cardiovascular events, reported Ryan."Individuals across all baseline levels of BMI had the same response."Deanfield reported on the relationship between weight measures at baseline as well as weight change after early treatment and CV outcomes.
"This suggests alternative mechanisms of improved CV outcomes with semaglutide beyond reduction in adiposity," remarked Deanfield."Many patients with overweight and obesity and not just those who lose weight, may receive CV benefit from semaglutide." Naveed Sattar, PhD, professor of metabolic medicine at the University of Glasgow, Scotland, commented on the results, reflecting on CV benefits and weight loss, and pointing out that they,"suggest the direct effect of semaglutide on the heart and blood vessels may be most responsible for its benefits on MACE but they cannot discount an additive benefit, even if small, of the weight loss on benefits seen.
Source: Healthcare Press (healthcarepress.net)
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