A dietary supplement derived from seaweed could help rein in the long term negative consequences of non-alcoholic fatty liver disease, says a study by Isabelle Harber, an undergraduate researcher from the University of Michigan.of her study at the American Society for Investigative Pathology annual meeting during the Experimental Biology 2022 meeting in Philadelphia.
“Non-alcoholic fatty liver disease is a growing public health challenge that is currently being addressed through an emphasis on lifestyle changes, especially diet, to prevent fat build-up in the liver,” says research team leader Muhammad Nadeem Aslam, MD, from the University of Michigan in Ann Arbor. “New approaches are needed because this doesn’t work for everyone.”Mice fed a high-fat Western diet developed diseased livers.
The research team used mice as their trial subjects, feeding them a high-fat diet to make them obese and develop non-alcoholic fatty liver disease and NASH. For 15 to 18 months, half of the mice were on this diet and ended up with “the full spectrum of liver disease, including advanced fibrotic changes and liver cancer.”
There were also short-term studies that lasted about 24 weeks where the research team “identified protein changes associated with the NASH and reduced tumour formation in the longer studies.”
Source: Healthcare Press (healthcarepress.net)
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