Research in the field of asymmetric catalysis over the past half century has resulted in landmark advances, enabling the efficient synthesis of chiral building blocks, pharmaceuticals, and natural products.A small number of asymmetric catalytic reactions have been identified that display high selectivity across a broad scope of substrates; not coincidentally, these are the reactions that have the greatest impact on how enantioenriched compounds are synthesized.
Typical discovery campaigns rely on a single model substrate, and thus select for high performance in a narrow region of chemical space. Here, we put forth a practical approach for using multiple model substrates to select simultaneously for both enantioselectivity and generality in asymmetric catalytic reactions from the outset.Multi-substrate screening is achieved by conducting high-throughput chiral analyses via supercritical fluid chromatography-mass spectrometry with pooled samples.
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Structures of a phycobilisome in light-harvesting and photoprotected states - NatureCryogenic electron microscopy structures of the Synechocystis phycobilisome—alone and bound with orange carotenoid protein—reveal detailed information regarding the biophysical basis of the control of cyanobacterial light harvesting.
Source: physorg_com - 🏆 388. / 55 Read more »
One pangenome to bind them all - Nature BiotechnologyOne pangenome to bind them all The pangenome provides a first glimpse of the scope of human genetic diversity. But its routine adoption into research and clinical practice faces several challenges why did you add a picture of half the article?
Source: NatureBiotech - 🏆 231. / 63 Read more »
DeepConsensus improves the accuracy of sequences with a gap-aware sequence transformer - Nature BiotechnologyDeepConsensus improves the accuracy of sequences with a gap-aware sequence transformer GoogleHealth PacBio acarroll_ATG marianattestad pichuan daniel_e_cook gunjan_baid 👀 $ARKG CathieDWood TashaARK skorusARK wintonARK sbarnettARK mfriedrichARK dpuellARK yassineARK
Source: NatureBiotech - 🏆 231. / 63 Read more »
Black Hole Discovery Helps to Explain Quantum Nature of the CosmosNew insights from black hole research may elucidate the cosmological event horizon
Source: sciam - 🏆 300. / 63 Read more »
A brainstem map for visceral sensations - NatureIn vivo two-photon calcium imaging analyses of sensory inputs from the gastrointestinal tract and upper airways in mice reveal spatial organization and coding principles of the interoceptive nervous system.
Source: Nature - 🏆 64. / 68 Read more »
Hippocampal astrocytes encode reward location - NatureAstrocytes can encode an expected reward location in familiar spatial contexts. Wow - really important findings! Congrats! Paywall
Source: Nature - 🏆 64. / 68 Read more »