Scientists Reveal Why Men and Women Experience Pain Differently

Scientists have uncovered differences between the sexes in the way pain is produced, pointing to potential new ways to target treatment for women and men.Researchers at the University of Arizona have identified functional sex differences in nociceptors, the nerve cells that produce pain.This discovery of 'male nociceptors and female nociceptors' may help scientists develop precise medicines for managing pain that are tailored to a patient's sex.

They selected these substances based on a previous study on chronic pain, which found that they had a sensitizing effect on nociceptors.Then, they tested how prolactin and orexin B affect the extent to which nociceptors react to low-intensity, pain-producing stimuli. The way we experience pain differs in intensity, depending on the stimulus. While touching a hot stove is high-intensity, a piece of clothing rubbing on sunburn is low intensity—but both are detected by the body as pain.

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