Scientists devise healthy mouse pups from two dads, without female DNA

The application is expected to take a long time in humans, maybe 10 years or more and it is unknown whether the eggs are safe enough to produce baby with two male DNA.A team of researchers from Osaka University in Japan proclaimed to have developed mouse pups from the two male DNA last year.

It was said back then that this holds promise for potential application in humans. In other words, two men could potentially have biological children together one day.this work provides insights that could facilitate infertility caused by sex chromosome or autosomal disorders, and opens the possibility of bipaternal reproduction.What makes it even more interesting is the fact that not only did these pups survive to adulthood, but they were also able to become parents themselves.

Subsequently, the cells were nurtured within an organoid created to imitate the environment of a mouse ovary. Following this, sperm from male mice was used for fertilization, and out of 630 embryos implanted into surrogates, seven mouse pups were successfully delivered., “The trick of this, the biggest trick, is the duplication of the X chromosome. We really tried to establish a system to duplicate the X chromosome.

This crucial step that ensures the egg contains half of the chromosomes from each parent once it is fertilized with sperm is thanks to the egg that is cultured in such a way that it naturally discards half of its chromosomes. “Should this technology become clinically viable in the future, it holds the potential to revolutionize IVF and offer hope to many infertile patients who have lost gametes due to disease,” said Aleksei Mikhalchenko, the first author of the study as noted inFAA clears JetZero’s futuristic blended wing design plane for flight

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