Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial - Nature Medicine

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Results from a phase 1 clinical trial show that a broadly neutralizing, HIV-specific antibody is durably expressed in vivo from a viral vector, highlighting an alternate approach for the delivery of antibodies in humans NIAIDNews HIV WorldAIDSDay

Richard M. SchwartzPresent address: ModeX Therapeutics, Natick, MA, USAVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

Joseph P. Casazza, Evan M. Cale, Sandeep Narpala, Galina V. Yamshchikov, Emily E. Coates, Cynthia S. Hendel, Laura Novik, LaSonji A. Holman, Alicia T. Widge, Preeti Apte, Ingelise Gordon, Martin R. Gaudinski, Michelle Conan-Cibotti, Bob C. Lin, Olga Trofymenko, Shinyi Telscher, Sarah H. Plummer, Diane Wycuff, William C. Adams, Adrian McDermott, Mario Roederer, Avery N. Sukienik, Sijy O’Dell, Jason G. Gall, Britta Flach, Travis L.

Biostatistics Research Branch Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USADepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USADivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA

 

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NIAIDNews Speaking of vaccines, A major study spearheaded by UCLA neurosurgeon Dr. Linda Liau recently published in JAMA oncology, showed improvement in brain cancer survival with a novel personalized vaccine called DCVax. $NWBO.

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