Revolutionizing Cancer Detection: New Machine Learning Method Deciphers Genomic “Dark Matter”

  • 📰 SciTechDaily1
  • ⏱ Reading Time:
  • 61 sec. here
  • 3 min. at publisher
  • 📊 Quality Score:
  • News: 28%
  • Publisher: 68%

United States Headlines News

United States Latest News,United States Headlines

Science, Space and Technology News 2024

ARTEMIS, a new machine learning tool by Johns Hopkins researchers, identifies repeat DNA sequences in cancer, enabling noninvasive diagnosis and insights into cancer genetics. It marks a significant advancement in cancer detection and monitoring, with potential applications in early detection and treatment response evaluation.

In a series of laboratory tests, the researchers first examined the distribution of 1.2 billion kmers defining unique repeats, finding them enriched in genes commonly altered in human cancers. For example, of 736 genes known to drive cancers, 487 contained an average fifteenfold higher than expected number of repeat sequences.

Finally, they evaluated whether the ARTEMIS blood test could identify where in the body a tumor originated in patients with cancer. When trained with information from the PCAWG participants, the tool could classify the source of tumor tissues with an average of 78%among 12 tumor types. The investigators then combined ARTEMIS and DELFI to assess blood samples from a group of 226 individuals with breast, ovarian, lung, colorectal, bile duct, gastric, or pancreatic tumors.

Reference: “Genome-wide repeat landscapes in cancer and cell-free DNA” by Akshaya V. Annapragada, Noushin Niknafs, James R. White, Daniel C. Bruhm, Christopher Cherry, Jamie E. Medina, Vilmos Adleff, Carolyn Hruban, Dimitrios Mathios, Zachariah H. Foda, Jillian Phallen, Robert B. Scharpf and Victor E. Velculescu, 13 March 2024,The work was supported in part by the Dr. Miriam and Sheldon G.

Source: Education Headlines (


Thank you for your comment. Your comment will be published after being reviewed.
Please try again later.
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:

 /  🏆 84. in US

United States Latest News, United States Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

Early detection may help Kentucky tamp down its lung cancer crisisA program launched to diagnose lung cancer earlier is beginning to change the prognosis by catching tumors when they're more treatable.
Source: CBSHealth - 🏆 480. / 51 Read more »

Activation of SOX17 Gene Allows Early-Stage Colon Cancer Cells to Evade Immune DetectionA new study finds that activating the SOX17 gene allows early-stage colon cancer cells to escape immune detection, presenting a potential target for preventing colon cancer.
Source: SciTechDaily1 - 🏆 84. / 68 Read more »

NYC Health + Hospitals/Gotham Health introduces 3D mammogram technology to enhance breast cancer detectionNYC Health + Hospitals/Gotham Health has unveiled a state-of-the-art 3D mammogram machine to revolutionize breast cancer detection.
Source: NYAmNews - 🏆 269. / 63 Read more »

Researchers hope bodily fluids hold key to earlier breast cancer detectionResearchers are working to use bodily fluids to noninvasively detect breast cancer sooner.
Source: wsyx6 - 🏆 444. / 53 Read more »

Franklin Primary Health and Delta Sigma Theta team up to fight colon cancerThis initiative centered on the importance of early detection and prevention of colon cancer.
Source: FOX10News - 🏆 581. / 51 Read more »

Are Multitumor Blood Tests More Hype Than Help?What the early cancer detection revolution means for you and your patients.
Source: Medscape - 🏆 386. / 55 Read more »